DoxyPEP | Equitas Health

What you need to know before GETTING DoxyPEP


DoxyPEP helps you prevent STIs.

Doxycycline Post-Exposure Prophylaxis (DoxyPEP) means taking the antibiotic doxycycline after sex without a condom (bareback sex) to help prevent sexually transmitted infections (STI). Think of it as a morning-after pill for STIs.

DoxyPEP lowers your risk of getting:

  • Chlamydia
  • Gonorrhea
  • Syphilis

DoxyPEP does NOT prevent:

  • HIV
  • Mpox
  • Other viral infections

Do you need DoxyPEP?

You might think about getting DoxyPEP if you have had:

  • Chlamydia, gonorrhea, or syphilis in the last 12 months
  • Sex without a condom with at least one person in the last 12 months. This includes oral, anal, or vaginal/front-hole sex.

Things to know about DoxyPEP

  • It is safe to take PrEP for HIV and DoxyPEP at the same time.
  • Doxycycline has been used to treat chlamydia and syphilis for decades.
  • Doxycycline is affordable, safe, and has mild side effects.

What you need to know before TAKING DoxyPEP


Taking DoxyPEP is as easy as 3, 2, 1!

  1. Take it within 3 days – or 72 hours – of sex without a condom.
  2. Take 2 tablets – or 200 mg – of doxycycline.
  3. Take it 1 time – or no more than one dose per day.


  • DO act fast. DoxyPEP works best if you take it within the first 24 hours after sex without a condom.
  • DO take with food and water. DoxyPEP may cause diarrhea, upset stomach, and loss of appetite.
  • DO wear sunscreen! You might sunburn more easily while taking DoxyPEP.


  • DON’T take more than 200 mg in one day
  • DON’T eat or drink dairy products.
  • DON’T take calcium, antacids, or multivitamins 4 hours before AND 4 hours after taking it.

More DoxyPEP Dos

  • DO get tested for STIs every 3 months or sooner if you have symptoms.
  • DO get tested if you have sex with someone who has a STI.
  • DO keep taking your HIV meds and make regular visits to your healthcare provider.

Talk to your doctor, nurse, or pharmacist if you have any questions or concerns.

HIV & STI Testing

In the new era of HIV, knowing is everything. Negative or positive, your HIV/STI test results can be the start of a new, healthy life.

Get PrEP!

One pill, one day at a time. 99% effective at preventing HIV transmission and free for most Ohioans.